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Hope Happens
Our Mission: To find a cure for ALS by funding progressive research and in the process create a new methodology for funding, researching and developing treatments for ALS and other neurological disorders.

Shout Out For Hope -
Join a Movement for Treatments and Cures

Everyone knows someone who has experienced a neurodegenerative disorder—ALS, Parkinson's, Alzheimer's, Huntington's, Epilepsy, Multiple Sclerosis, brain and spinal cord injury, Cerebral Palsy, Muscular Dystrophy, stroke, and many more. We share that bond of knowing someone. Now we share hope. Our hope is to control these disorders by finding treatments and cures

Like us, these disorders are also connected. When scientists collaborate and discover breakthroughs for one disorder, that success can lead to treatments and cures for another... and another... That's why we have a reason to rise, a reason to collaborate, a reason to start a movement, a reason to hope. We call this movement Shout Out for Hope

See this Shout Out from our supporter, Lori Schneider, who empowers those living with MS:

Thank You for Taking the Ice Bucket Challenge!

We would like to express our heartfelt gratitude to all who took the #IceBucketChallenge and contributed to Hope Happens for Neurological Disorders or posted their video on the Shout Out for Hope app. We are truly grateful for your gifts as well as your help in spreading awareness! Together, we can #strikeoutALS.


Summer 2014 Newsletter now available

We would like to thank all the friends of Hope Happens for Neurological Disorders who have made the 10th Annual Evening of Hope possible. This year's event was the most financially successful Evening of Hope to date and raised more than $240,000 for the Hope Center. We hope that those of you that could join us enjoyed the evening and the performance by the Marcus Roberts Trio.

The Summer newsletter is now available for viewing and download and reviews some of the highlights of the annual gala. Just click on the picture to the right to view the current issue of Hopelines.

We were thrilled that Dr. William Peck, MD, former Dean of the Washington University School of Medicine, accepted this year's Spirit of Hope Award and we are grateful for his instrumental role in the partnership between Hope Happens and Washington University.

Click here to see the photo gallery of the event or click here to see the video highlights from the event.

Past Pilot Grant recipient Dr. Chris Weihl demonstrates research equipment.

Your Gifts at Work

Make a Difference Today // We all know that finding cures and treatments for neurological disorders is extremely urgent. Your generosity and continued commitment supports ongoing projects of our dedicated Hope Center doctors and scientists who are making progress in the fight against all neurological disorders every day.

Help us to continue the fight by making a tax-deductible gift today. Donate online or mail your contribution to our office. Any amount you feel comfortable giving is deeply appreciated. With your support, we can provide hope today in the lives of people with neurological disorders.

Click here for our brochure

Hope Center Pilot Projects

Promoting axonal regeneration in models of ALS via activation of the preconditioning response in iPSC-derived human neurons

From left to right: Principal investigator Aaron DiAntonio (WUSTL Developmental Biology), Co-investigators Jeffrey Milbrandt (WUSTL Genetics) and Timothy Miller (WUSTL Neurology).

The researchers' objective is to find new treatments for neuronal injury and disease by promoting regeneration of axons through the body's natural response to injury. This response, known as 'preconditioning', results in stimulation of an improved regenerative response to a subsequent neuronal injury. The long-term goal is to identify candidate drugs and/or genes that can activate the response without the need for a prior injury.

Click here to find out more about the axonal regeneration project.

TREM2 signaling as a biomarker and therapeutic target in ALS

From left to right: Principal investigator Matthew Harms (WUSTL Neurology), Co-investigators Marco Colonna (WUSTL Pathology and Immunology) and Timothy Miller (WUSTL Neurology).

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, is caused by the relentless death of motor neurons in both the brain and spinal cord, which results in progressive paralysis of the body's muscles. Eventually the disease leads to death when ability to breathe is lost. The loss of neurons in ALS is accompanied by increased activity in certain immune cells; recent research has shown these cells to be active participants in the disease process. The objective of this project is to determine if and how the TREM2 receptor pathway can be used to bias the body's immune cells away from disease progression and towards the regeneration of neurons.

Click here to find out more about the TREM2 project.

Using biosensors to identify therapy-driven brain reorganization in children

From left to right: Principal investigator Bradley Schlaggar (WUSTL Neurology), Co-investigators Nico Dosenbach (WUSTL Neurology) Catherine Lang (WUSTL Physical Therapy) and Steve Petersen (WUSTL Neurology).

Brain injury is the main cause of disability in children. Following brain injury, children often compensate remarkably well. It is thought that the developing human brain compensates for injuries through use-driven reorganization of the remaining intact brain structures, but the mechanisms remain unknown. Understanding these mechanisms is important for designing neurorehabilitative treatments that enhance recovery. This project will pioneer the use of wearable movement biosensors in children to provide continuous measures of three-dimensional extremity movement. Merging advanced MRI and biosensor technologies will identify the links between brain regions most important for improving real-world movement in children. Such links can then be targeted with medications, therapies, brain stimulation and neurofeedback.

Click here to find out more about the brain reorganization project.

101 South Hanley Road
Suite 1320
St. Louis, MO 63105

p: 314-725-3888
f: 314-725-3892

Christopher Wells Hobler
1965 - 2005

Chris lost his battle against ALS on Wednesday, February 16, 2005, surrounded by his loving wife, family, friends and caregivers.
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The Hope Center
for Neurological Disorders

HOPE HAPPENS was formerly

ALS HOPE: The Chris Hobler/James Maritz Foundation